First, it's not true that the Lagrangian density is restricted to have first-order space and time derivatives. The example of the scalar field,
L=12∂μϕ∂μϕ−12m2ϕ2+Lint(ϕ)
is a clear counterexample.
Now, following Weinberg, QFT I, section 10.7 on the Kallen-Lehmann representation, we can show (I won't reproduce the full derivation here) that inclusion of higher-order derivatives in the L−Lint (the free Lagrangian) is inconsistent with the positivity postulate of quantum mechanics. The mathematical statement is that the exact two-point function -- the ϕ-propagator -- must behave as
Δ′(p)⟶p2→∞1p2.
From the perspective of effective field theory, however, it is possible to have derivative couplings of any finite order in a local theory (infinite orders are inherently non-local), as long as we introduce a dimensional (usually mass) scale of the appropriate dimension at each order. (See Motl's answer to Why are differential equations for fields in physics of order two? for a full explanation.)
The answers given earlier are all incorrect for one or more reasons. See the comments.
This post imported from StackExchange Physics at 2014-07-13 04:40 (UCT), posted by SE-user MarkWayne