Strong CP violation happens when the theta term gives a complex phase, but there are two values where the effect is real, $\theta=0$ which gives no phase for instantons, or $\theta=\pi$, which gives a -1 phase for each instanton. Do we know we are at 0, not at $\pi$?
For instance, do we have lattice simulations or other theoretical estimates for the $\pi$ version of QCD showing disagreement with the hadron spectrum? This might not be easy, as there is a sign problem.