Often, instead of R3n/Sn, you may want to resolve the singularity. Let me explain a toy model where that resolution appears naturally.
Consider n identical particles on C with the configuration space Mn=(Cn−Δ)/Sn. You can think of this space as the space of unordered eigenvalues of n×n matrices over C, i.e. Mn=Matn(C)diag/GLn(C), where Matn(C)diag is the space of diagonalizable matrices with distinct eigenvalues and GLn(C) acts by conjugation.
A heuristic argument (which is precise when the action of G is nice) shows that T∗(M/G)≅T∗M//G, where // is the Hamiltonian reduction. In my case, there is a well-known compactification of T∗Mn called the Calogero-Moser space Cn obtained by the Hamiltonian reduction of T∗Matn(C) along some orbit.
Cotangent bundles have natural quantizations (functions are replaced by differential operators on the base and the Hilbert space is just L2 functions on the base), and the quantization of the Calogero-Moser space Cn is obtained by a procedure called the quantum Hamiltonian reduction from the quantization of T∗Matn(C).
For a reference, see Etingof's lectures http://arxiv.org/abs/math/0606233v4. In particular, see proposition 2.6. Note, that he is more precise than I am, and so considers the action by PGLn(C) since it does not have any center.
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